True picture of cutaneous and mucosal lesions of Behcet’s disease in 3751 cases

Authors

  • AH Nadji
  • AR Jamshidi
  • Ch Chams
  • F Davachi
  • F Gharibdoost
  • F Shahram
  • H Chams
  • M Akbarian
Abstract:

Background: There is not yet a pathognomonic laboratory test for the diagnosis of Behcet’s Disease (BD). The diagnosis is therefore based on clinical manifestations. Mucocutaneous lesions are the most important and the most frequent clinical manifestations of BD. Objective: To study the mucocutaneous lesions systematically. In a great number of patients. Some of these clinical pictures are poorly defined in the literature, and some of them are still unknown. Methods: From 1992 to 1998 we screened systematically all patients attending the Behcet’s Disease Research Unit (BDRU), Rheumatology Research Center, Tehran University for Medical Sciences, for mucocutaneous lesions. Only recurrent lesions were taken in consideration. A total of 3751 patients were seen and registered in our database. The mean number of new patients seen every year, during the last 10 years, was 302 patients per year. Results: Besides the classical lesions, we observed unusual and rare forms of mucous membrane, cutaneous, and subcutaneous lesions. Mucous Membrane lesions: 1) Oral aphthosis is the most important lesion of BD (96.1%±0.6). They are not different from other aphthosis, but they are often smaller. There are also the Punctiform, the Miliaria, and the Herpetiform aphthosis. 2) Genital aphthosis was seen in 63.9%±1.5 of patients. In females they are often larger, deeper, and very painful. Giant forms are seen sometimes. In male they are seen more often on the scrotum. Recurrent conjunctival aphthosis is rare. It is small and ephemera. 3) Ulceration and erosions are different from aphthous lesions. They can take multiple and various shapes without a specific characteristic. 4) Purpura and erythema may also be seen on the mucous membrane. Skin Lesions: Is the second most frequent manifestation of BD. It was seen in 67.4%±1.5 of the patients. The pathergy phenomenon, which is a skin hyper reactivity to trauma, was seen frequently in BD. The most important cutaneous lesions of BD is the pseudo folliculitis. It is a small erythematous lesion, surmounted in the center by a round and non-acuminated pustule, which is dome shaped, sterile, and without hair in the center. They are situated mainly on the lower limbs. Other lesions are 1) Small round erythemato-edematous lesions. 2) Cutaneous aphthosis, which is the most characteristic lesion of BD. It is a round and punched out ulceration with a white yellowish necrosis on the bottom. It leaves a scar after healing. 3) Small nodules. 4) Behcet’s Cellulitis; it is a large painful erythematous lesion. It is not infectious nor a superficial thrombophlebitis. In the literature, it was mistakenly taken as Sweet syndrome. The biopsy in all lesions shows a vasculitis, leucocytoclastic or lymphocytic. Subcutaneous Lesions: Erythema nodosum is seen in 22.8%±1.3 of cases. It is a frequent and relapsing lesion. It is a subcutaneous node, painful, red mauve, with different sizes, and often surrounded with an erythematous and edematous ring. Other lesions are rarely seen 1) Subcutaneous lesions, like Erythema Induratum of Bazin. 2) Suppurative panniculitis. Conclusion: Our study showed a wide variety of muco-cutaneous lesions. The lesions are not specific of BD, but they have their own characteristic. Those characteristics, along with the coexistence of different forms, can help to diagnose BD.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the role of type-d personality, social support and self-compassion in prediction of health behaviors in coronary heart disease patients

نظر به اهمیت و تاثیر روزافزون عوامل روانی – اجتماعی در سلامت جسمی و تاثیر عوامل روان شناختی در بروز بیماریهای مختلف از جمله بیماریهای قلبی و عروقی این پژوهش با هدف کلی بررسی ارتباط تیپ شخصیتی d ، حمایت اجتماعی و خود دلسوزی در پیش بینی رفتارهای بهداشتی بیماران کرونر قلبی و تعیین تفاوت بین بیماران کرونر قلبی با و بدون جراحی و افراد سالم در این متغیرها و رفتارهای بهداشتی آنان، انجام گرفت. جامعه آ...

15 صفحه اول

faculty of psychology and social sciences group of anthropology master thesis in major of anthropology

چکیده پایان نامه (شامل خلاصه، اهداف، روش های اجرا و نتایج به دست آمده): کار جمع آوری گو یش های محلی در سال های اخیر شتاب امیدوار کننده ای به خود گرفته است. شاید از بارزترین اهداف جمع آوری گویش های مختلف، ثبت و ضبط آن، جلوگیری از نابودی و مهمتر از همه حل مشکلات دستوری زبان رسمی باشد. دقت در فرآیند های زبانی گویش های محلی نوع ارتباط مردم نواحی مختلف با پیرامون نشان را به ما نشان خواهد داد. از س...

ideological and cultural orientations in translation of narrative text: the case of hajji baba of isfahan

در میان عواملی که ممکن است ذهن مترجم را هنگام ترجمه تحت تأثیر قرار دهند، می توان به مقوله انتقال ایدئولوژی از طریق متن یا گفتمان اشاره کرد. هدف از این تحقیق تجزیه و تحلیل جنبه های ایدئولوژیکی و فرهنگی متن مبدأ انگلیسی نوشته جیمز موریه تحت عنوان سرگذشت حاجی بابای اصفهانی ( 1823) و ترجمه فارسی میرزا حبیب اصفهانی(1880) بوده است.

Inverse correlation between glutathione peroxidase activity in psoriatic cutaneous lesions and the severity of the disease

Background: Psoriasis is a chronic-relapsing inflammatory skin disorder, in whose pathogenesis oxidative stress is suggested to be involved. Among different enzymes that play a role in maintaining the cellular redox balance, we aimed to assess the alteration of glutathione peroxidase (GPX) activity in cutaneous lesions and its correlation with the disease severity, firstly, to support the possi...

full text

synthesis of sulfides from alcohols and thiols in solvent-freeconditions and deoxygenation of sulfoxides

کاتالیست یک سنتز جدید برای تیواترها توصیف شده است. واکنش الکل ها با آریل، هتروآریل و آلکیل تیو ل ها درحضور 1،3،5- تری آزو- 2،4،6- تری فسفرین-2،2،4،4،6،6 هگزاکلراید ((tapc به عنوان یک کاتالیست موُثر، بازده های خوب تا عالی از تیواترها را حاصل می کند. علاوه براین، واکنش تحت شرایط بدون فلز و بدون حلال پیش می رود، بنابراین یک مکمل جالب برای روش های شناخته شده سنتز تیواترها ارائه می دهد. یک مکانیسم ا...

15 صفحه اول

role of cultural iran in promotion of multilaieralism in central asia and caucasus

cultural iran is a scope that is more extended than the political territories of iran as a political unit. this concept means that cultural geography(mehdi moghanlo-1383-1) of iran is greater than its political geography which, according to history, has a long history extending west-east from kandahar to the euphrates and north-south from the persian gulf to the caucasus including transoxiana a...

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 1  issue 3-4

pages  23- 28

publication date 1998-07-01

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023